Abstract
Background and Aims: White (WAT) and brown (BAT) adipose tissue, are respectively responsible for lipid storage and non-shivering thermogenesis, a process mediated by mitochondrial uncoupling protein 1 (UCP1) which uncouples oxidative phosphorylation from ATP production, leading to heat production. This process can be triggered by cold exposure, caloric excess, and the immune system. Recently thermogenesis has been associated with plasma lipoprotein transport system. Specifically, APOE3 is shown to have a bimodal effect on WAT thermogenesis while APOE2 and APOE4 differentially affect BAT and WAT thermogenesis in processes highly modulated by APOA1. Furthermore, APOA1 deficiency is associated with no measurable UCP1 levels in WAT of mice fed high fat diet.
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