Abstract
Hyaluronic acid hydrogels (HAHs) were synthesized by immersing the HA microbeads crosslinked with divinyl sulfone in phosphate buffered saline solution to assess the responses of tissues to the implant by means of the subchronic systemic toxicity and the intradermal implant test. The HAHs, prepared by the microbeads with an average diameter of 140 μm and a swelling rate of 800 to 1200%, exhibited a porous network channeled with 10 μm pores. The HAHs retained their space and structure by maintaining over 95% of the initial volume 12 weeks after injection to a rabbit. The histological analysis indicated that an acute inflammation, occurred in the rabbit 4 weeks after injection, was alleviated dramatically after 8 weeks. No capsule was formed. The HAHs had no subchronic systemic toxicity under the condition of this study and were considered non-irritant. The implants were excellent in biological synthesis and transplantation as evidenced by non-capsule reaction and disappearance of inflammatory cells. It can be concluded that the implants of HAHs are clinically safe and effective.
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