Tissue Respiration of Thyroidgland Obtaind from Exophthalmic Goiter, Toxic Goiter and Simple Goiter

Abstract

The number of these diseases which I could study was twentoy in all. Ten of them exophthalmic goiter, seven of them toxic goiter, simple goiter was one, and nodural goiter was two. About nodural goiter I measured normal tissue for the control.As for respiration rate (QO2) exophthalmic goiter and also toxic goiter are high, simple goiter and the control are low, Simple goiter is equal normal fissure, but I can't say every time exophthalmic goiter is higher than that of toxic goiter, because some of toxic goiter is higher than that of exophthalmic goiter.So that I made up a respitation type for example and found at all time the oxygen consumption was very variable about thyroidtissue. In respect of this respiration type I could differ. exophthalmic goiter from toxic goiter clearly.Apparatus Barcraft, medium phosphate solution, slice of thyroidgland about 80mg drying weight are used and measured accuarately the difference of the manometer which occured during five minutes.I found following phenomena:1) At the first period of respiration type the consumption of exophthalmic goiter is lower and after regular interval becomes higher consumption, and, on the contrary toxic goiter at first higher and falls down quickly. Simple goiter and two normal tissue are not so variable, slowly fall down.2) By the microscopic observation of the epitheliums, when it is hyperplasia, the respiration rate is high and hypoplasia low. And when follicle containes a plenty of colloid droplets the consumption is also high, however the opitheliums is not hyperplasia.3) Determination of the respiration rate is connected with relation between the amount of medium and tissue.4) By addition of inorganic iodide the follicle cannot make thyreoglobulin in the epitheliums, but iodide does not disturb to make up thyroxin from the thyreoglobulin, colloid droplets which was stored in the follicle, and I think it is true that surviving thyroidtissue is always stimulating itself by its own secretory function.5) There is no relation between tissue respiration of the thyroidgrand and basal metabolism rate.