Abstract
Male broiler chicks (Hubbard-Hubbard) were fed graded levels (0, 0.1, 1.0, 5.0, and 20 ppm) of formulated pentachloronitrobenzene (PCNB) for 8 weeks. Each treatment consisted of 50 randomly selected birds (approximately 25 birds in each of two replicates). No treatment-related changes in body weight or organ weight were observed. Histopathologic examination of brain, liver, testes, pancreas, small intestine, ventriculus, spleen, kidney, lung, and heart failed to reveal lesions in either control or treated groups. Traces of PNCB residue and its major metabolite, pentachloroaniline (PCA), were occasionally found in body organs (>0.01 ppm) but were absent from adipose tissue. Hexachlorobenzene (HCB), a trace contaminant of PCNB, accumulated in adipose tissue to a level of 25 to 50 times over the concentration in the feed. After 7 weeks, rations containing PCNB were withdrawn and nonmedicated feed was provided. After 5 weeks of withdrawal, >0.5 ppm of HCB remained in adipose tissue of birds that had been fed 20 ppm of PCNB.
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