Abstract
This chapter discusses the response elicited by the stimulation of tissue receptors investigated in numerous experiments on adult anesthetized cats during perfusion with oxygenated Tyrode solution of various organs (small intestine segments, stomach, spleen, and kidney) connected to the body only with neural connections. Systemic arterial pressure, respiration, and summated bioelectrical activity in afferent fibers were recorded and responses evoked by tissue receptors' stimulation with acetylcholine and nicotine were investigated. In some experiments, Tyrode solution saturated with carbon dioxide (pH 7.24-7.28) and added buffer solution was used. Nicotine, acetylcholine, and CO 2 ,-containing Tyrode solution caused an increase in systemic arterial pressure, respiratory stimulation, and an enhancement of summated bioelectrical activity in afferent fibers. These effects could be abolished by previous administration of Novocain or cocaine into the vessels of the perfused organs. The responses were restored when the perfused organs were washed with Tyrode solution. Anoxic solutions produced similar, but less pronounced effects in 50% of animals.
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