Year-end Sale % OFF 
Abstract
In a graded model of the calcium paradox phenomenon (minimal and total) the presence of the beta-blocker propranolol (5 X 10(-6) M) in the perfusion media (10 min prior to, during and 5 min following calcium-free perfusion) had no effect upon tissue injury. Propranolol pretreatment (three days prior to the experiments) significantly reduced the myocardial enzyme release during calcium repletion in the minimal calcium paradox. The presence of the alpha 1-blocker prazosin (1 X 10(-7) M) in the perfusion media (10 min prior to, during and 5 min following calcium-free perfusion) afforded no protective effects. It is concluded that the release of endogenous catecholamines may not be an important factor contributing to myocardial injury in the calcium paradox, and that consequently beta- or alpha 1-adrenergic blockade has little if any protective properties in this form of myocardial injury.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
