Abstract
TPA level were determined with an enzymelinked immunoabsorbent assay in plasma of 49 patients with cerebral infarction, 6 with cerebral hemorrhage and 24 healthy controls. Infarct patients were assigned, according to the arterial lesions responsible for stroke, to cortical and perforating arterial group (CI and PI group). TPA levels in 25 specimens in PI and 6 in CI group within 4 weeks since the onset were 9.77±3.54ng/ml and 12.86±2.62ng/ml respectively. Plasma TPA levels in subsequent period after 4 weeks from the onset were 13.58±3.49ng/ml in 9 specimens obtained from CI, 8.14±2.56ng/ml in 17 from PI and 8.14±2.95ng/ml in 6 from hemorrhagic group, the level in CI group was significantly higher compared with the value of PI or hemorrhagic group.The values throughout the period of this trial were 13.29±3.09ng/ml in 15 specimens from CI and 9.11±3.24ng/ml in 42 from PI group, the level in CI group was significantly higher than the value in PI group. TPA level was directly proportional to β-thromboglobulin. These results demonstrate clearly important role of TPA in cerebral infarction originated from ischemic lesion in cortical arterial region. In conclusion, determination of plasma TPA is available for clinical observation of atherothrombotic disorders in cerebral infarction.
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