Abstract
Photodynamic therapy typically uses visible light to locally activate a therapeutic agent, but the tissue-depth penetration of visible light is weak. As a solution, Idris et al. prepared a nanoparticle that contained a component able to convert a near-infrared (NIR) light trigger into visible light, in addition to two photosensitizers that generate cytotoxic oxygen radicals in response to visible light. The resultant laser NIR-activated nanoparticles reduced the viability of mouse melanoma cells in vitro; furthermore, injection and activation of this agent in melanoma-bearing mice slowed tumour growth in vivo.
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