Abstract
Abstract Lymphocyte suspensions from man and primates show a high proportion of cells adhering to sheep erythrocytes (E) forming rosettes (1–3). The binding of E to lymphocytes is dependent on temperature and is probably not immunologic in nature because 20 to 40% of normal human peripheral blood lymphocytes form rosettes when incubated with E (1). It appears as if the lymphocytes which have receptors for E constitute a subpopulation of lymphoid cells which are thymus dependent or derived (T) since almost 100% of human thymocytes form this type of rosette (1). A number of reports validate the use of certain membrane markers for the characterization of lymphocyte populations. Distinct markers for “T” and bone marrow-derived (“B”) type cells have been described on the membrane of mouse lymphocytes: the theta (θ) alloantigen (4–6), the receptors for a modified complement component (C3) (7–9) and the membrane-bound immunoglobulins (8, 10, 11).
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