Abstract
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Laurén, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters.
Highlights
We assessed the levels of matrix metalloproteinases (MMPs)-2 and MMP-9 in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography
Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Lauren, WHO and tumour-node-metastasis (TNM)
Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters
Summary
We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Lauren, WHO and tumour-node-metastasis (TNM). The prognostic significance of the MMP-2 and MMP-9 levels for the survival of patients with a gastric carcinoma was Correspondence: HW Verspaget, Department of Gastroenterology and Hepatology, Building 1, C4-P012, University Hospital, PO Box 9600, 2300 RC Leiden, The Netherlands Received 10 August 1995; revised 29 January 1996; accepted 22 February 1996 evaluated using Cox's proportional hazards method in univariate analysis, and multivariately by addition to a broad selection of established clinicopathological variables. Follow-up had to be at least 2 years and ended in the event of death or when still alive the last follow-up date before the common closing date (follow-up range 0.5-81 months)
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