Abstract
When spleen or lymph node cells from mice infected with or immunized against lymphocytic choriomeningitis virus are incubated with living or killed virus in vitro, a cell-free cytotoxic factor (CT) is made. Production of CT appears immunologically specific in that it is formed only when LCM immune lymphoid cells are incubated with LCM virus and not with either mumps or lactic dehydrogenase virus or human immunoglobulin G (HuIgG). Once released, the biological activity of the CT is nonspecific as it injures both viral infected and noninfected target cells. The time required for elaboration and action of CT, as well as its effect on both infected and noninfected cells, suggests that the cellular injury it causes may perhaps be different from the immunologically specific, direct in vitro injury caused by immune lymphoid cells.
Published Version
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