Abstract
Objective:Breast cancer is one of the most important public health problems among women worldwide. It is a major cause of morbidity especially among women in developing countries including Thailand. The purpose of this study was to study the expression of LPHN3 protein in normal breast tissue compared to breast cancer tissue. Methods: We had studied the expression of LPHN3 in 65 breast tissues using an immunohistochemistry method. The association between LPHN3 expression and breast cancer metastasis to nearby axillary lymph nodes was also examined. Results:Among the 65 breast cancer and normal breast tissues examined, LPHN3 expression with an immunohistochemistry index (IHC index) greater than 4 was more frequently found in breast cancer tissues than in normal breast tissues (P-value = 0.001, OR (95% CI) = 7.04 (2.16-23)). Moreover, a high expression of LPHN3 (IHC index > 4) was more frequently found in breast cancer tissues with negative axillary lymph nodes than in those with positive ones (P-value = 0.038, OR (95% CI) = 0.25 (0.07-0.96)). LPHN3 protein might be a new metastasis suppressor gene in breast cancer and a marker for breast cancer metastasis prevention. Conclusions:The present study indicated that a decrease of LPHN3 protein expression in breast cancer tissue might be a marker indicating the aggressiveness of breast cancer. These results also suggested that a decrease of LPHN3 expression could be functionally involved in breast cancer progression and metastasis.
Highlights
Breast cancer is the most common cancer among women worldwide affecting 2.1 million persons annually, and it is the leading cause of cancer death among women (WHO)
The present study indicated that a decrease of LPHN3 protein expression in breast cancer tissue might be a marker indicating the aggressiveness of breast cancer
These results suggested that a decrease of LPHN3 expression could be functionally involved in breast cancer progression and metastasis
Summary
Breast cancer is the most common cancer among women worldwide affecting 2.1 million persons annually, and it is the leading cause of cancer death among women (WHO). A better understanding of the molecular regulation involving breast cancer progression may help to discover effective molecular markers to evaluate diagnosis and prognosis. These will help increase the success rate of therapy with lower mortality (Wang, 2017) because tumor metastasis can lead to poor chances of survival for patients (Jemal et al, 2008). An infiltrating duct carcinoma with regional lymph node metastasis is the most common breast cancer type among Thai patients (Kotepui and Chupeerach, 2014). Metastasis is the final progression of solid cancer This involves tumor cell intravasation, circulation, extravasation, angiogenesis, and continued growth in other organs and tissues (Valastyan and Weinberg, 2011). LPHN3 expression related to axillary lymph node metastasis was examined
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