Abstract
Tissue engineering and regenerative medicine (TERM) has been a growing area of research since the 1990’s. Since the inception of this burgeoning field, cartilage has been a target tissue. It was thought this would be a relatively simple tissue to engineer, consisting of one cell type and no blood vessels or nerves. Moreover, there was and remains an unmet clinical need for functional repair of cartilage defects. This led to the development of one of the first cell therapies in clinical application (i.e.
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