Tissue Engineering: Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions (Adv. Biosys. 9/2020)

Abstract

To overcome the limitations of traditional organ chips, in article number 2000133, Ryan A. Koppes and co-workers have implemented a “cut and assemble” manufacturing technique to exploit the meniscus pinning effect, via GelPins, to constrain 3D biomaterials. These GelPins enable the formation of discrete, yet contiguous hydrogel structures in both x-y and z planes within custom microfluidic devices, facilitating future investigation of innervation and heterogenous tissue interactions.