Abstract
AbstractCartilage is a dense connective tissue that functions to withstand and distribute load (1). Articular cartilage lines the ends of long bones and distributes loads across the joints. It consists of a dense collagenous matrix (primarily collagen type II, with smaller amounts of other collagens, including types I, V, VI, IX, and XI), embedded in a high concentration of aggregating proteoglycan, aggrecan. The collagen provides tensile properties, and the proteoglycans confer compressive properties and resiliency. There is a sparse population of a single cell type, the chondrocyte, distributed throughout the tissue. These cells synthesize and maintain the cartilaginous matrix in a regulated fashion that involves breakdown of matrix components, release of proteolytic products from the tissue, and synthesis and incorporation of new components into the matrix.KeywordsArticular CartilagePolylactic AcidPolymer FoamConstruct CultureDense Connective TissueThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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