Tissue Engineering: In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications (Adv. Healthcare Mater. 19/2020)

Abstract

In article number 2000981 by Pierre Weiss and co-workers, an in situ forming, single-component hyaluronic acid hydrogel is reported based on the pH-triggered condensation of silanols into siloxanes. In vitro, cytocompatible hydrogels with tunable mechanical properties are obtained by tuning the crosslink density. In vivo, the hydrogel's degradability can be adapted, while elicitating minimum inflammation. Silanized hyaluronic gels are potent minimally invasive vehicles for tissue engineering.