Abstract
Two Ricinus lectins, ricin D and castor bean hemagglutinin (CBH) were iodinated with different numbers of diiodotyrosine (DIT) per molecule and trace labeled with iodine-125. The distribution in rat tissues after intraperitoneal and intravenous injection was investigated as a function of the degree of iodination of the lectins. A high specific affinity to the pancreas was found after intraperitoneal injection. About 6% of the administered dose/gram was localized in the pancreas at 30 min after injection of 3 DIT, 125I-CBH and the pancreas to liver ratio was 16:1 (% dose/g). In the case of ricin D, the uptake in the pancreas was about 3% dose/g, at 30 min after injection of 3.6 DIT, 125I-ricin D and the pancreas to liver ratio was 12:1 (% dose/g). No uptake, except in the liver, was observed after intravenous injection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The International Journal Of Applied Radiation And Isotopes
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
