Abstract
The ability to transaminate and decarboxylate [ i- 14C]leucine is widely distributed in guinea pig tissue and is present early in fetal life. The peripheral white blood cell in the human can also transaminate and decarboxylate [ i- 14C]leucine, but the red blood cell, placenta and adult muscle can not. Using sodium α-[ i- 14C]ketoisovalerate as substrate, placental mitochondria and muscle homogenate produced only minimal amounts of decarboxylation of questionable significance. Fractionation of guinea pig liver revealed the cytoplasmic decarboxylase activity to be concentrated in the mitochondrial fraction.
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