Abstract
Tissue distribution and elimination of oxytetracycline (OTC) following oral administration were evaluated in perch and black seabream. Perch and black seabream were treated with OTC at a dose of 100 mg OTC kg −1 weight body per day for 5 days in 20.4±0.6 and 17.3±0.8 °C seawater, respectively. At different times after oral administration, eight perch and five black seabream were randomly selected from the tank and killed. Blood, muscle, liver and kidney tissues were analyzed for OTC by high-performance liquid chromatography (HPLC). The tissue distribution profiles of OTC in both species were found to be very similar; OTC tissue concentrations decreased in the order liver>kidney>muscle≥blood at the conclusion of the OTC treatment period. However, OTC tissue concentrations in black seabream were much higher than those of perch. The results show that OTC concentrations in the muscle of perch and black seabream fell below 0.05 μg g −1 at Days 8 and 30 post-medication, respectively. These results help the Chinese fishery department to lay down the current guidelines on OTC withdrawal time for farmed fish.
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