Tissue deposition patterns after chronic inhalation exposures of rats and guinea pigs to aluminum chlorhydrate

Abstract

Groups of rats and guinea pigs were exposed to 0.25, 2.5, or 25 mg/m 3 aluminum chlorhydrate (ACH), the principle ingredient in antiperspirant deodorants, by inhalation for periods up to 24 months. The tissue deposition pattern of aluminum was determined as well as the effect of ACH on body weight gain and organ/body weight ratios. Decreases in body weight were seen in rats exposed to 2.5 and 25 mg/m 3 ACH. Guinea pig weights were unaffected. Increases in lung to body weight ratios were seen in both species. The A1 appeared to be primarily contained in the lung. The only other organs with significant concentration of A1 were the peribronchial lymph nodes in the high dose guinea pigs and the adrenal glands of the medium- and high-dose rats.