Abstract
A routine procedure for potency testing of smallpox vaccine in monkey tissue cultures (standing tubes) is described. With ten tubes per tenfold dilution of virus the standard deviation of single titers was about 0.2 log unit. Variation of the susceptibility of different cell lots was generally small and did not justify correction with standard titers. The correlation between tissue culture titers and public primary vaccination results was satisfactory (correlation coefficient 0.8), though the latter probably incorporated large sampling errors.
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