Abstract
Tissue culture has been used for the study of the morphogenetic field within the tooth and within the jaw. In studies using a culture medium composed of chicken embryo extract and fowl plasma it was found that when isolated tooth rudiments were explanted at an early stage of differentiation, normal cusps formed and histological differentiation of all dental tissues occurred. In pieces of jaws explanted at a very early stage before the formation of tooth germs whole teeth developed, those from the anterior part of the jaw forming incisors and those from the posterior portion molars: these findings illustrate the presence of a morphogenetic field within the jaw and within the tooth germ itself. In tooth germs cut into two before cusps were present, and in which the two halves were grown in tissue culture, regulative changes occurred and each part formed a whole tooth. When tooth germs were grown in a chemically defined medium, cusps formed during the period of cultivation and there was histological differentiation of the component cells and tissues of the tooth germ.
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