Abstract
Liopid depletion, or hemorrhage and necrosis of the adrenal cortex, has been recorded by numerous investigators of pantothenic acid deficiency (Daft and Sebrell, 1939; Nelson, 1939; Ashburn, 1940; Mills et al., 1940; Morgan and Simms, 1940 (a); Salmon and Engel, 1940; Mushett and Unna, 1941; Supplee et al., 1942 and Deane and McKibbin, 1946). Ashburn (1940) suggested that these morphological changes may be accompanied byvarying degrees of adrenal cortical insufficiency. The occurrence in deficient animals of sudden prostration, gastro-intestinalsymptoms (Shaeffer et al., 1942) and a terminal, picture consistent with severe dehydration would seem to support this concept. Also consistent with this premise is the decreased resistance to water intoxication in pantothenic acid deficient animals observed by Gaunt et al., 1946. Furthermore, pantothenic acid deficient rats have been observed to consume larger quantities of salt when on a self-selection salt intake than do similarly treated controls (Supplee et al...
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