Abstract
The objective of this study was to examine relations between basal metabolic rate (BMR) and cadmium (Cd) accumulation in the liver, kidneys, and duodenum in mice. The 5-month-old mice selected for high (H) and low (L) BMR were exposed for 8weeks to 0, 10, and 100μgCd/mL of drinking water. The H-BMR mice showed significantly higher concentrations of Cd in the liver (47-79%), kidneys (61-70%), and duodenum (74-100%) than L-BMR animals. The tissue Cd accumulation also positively correlated with the duodenal iron which, in turn, was positively associated with BMR (Spearman R (s) = 0.81, P = 0.0004). The data indicate that tissue accumulation of Cd in mice is linked to BMR; the correlation between tissue Cd and duodenal iron suggests an involvement of iron transport pathway in the accumulation of Cd.
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