Abstract
Differences in tissue water state have been measured in normal and malignant breast tissues. Broadband Diffuse Optical Spectroscopy (DOS) has been used to acquire 650-1000 nm absorption spectra of normal and tumor breast tissues from 7 patients <i>in vivo</i>. The absolute values of spectral differences between normalized tissue water spectra and pure water spectra were combined and divided by the number of points in the sum to form the bound water index (BWI). In all subjects, the average BWIs of line scan points were significantly lower in tumor tissues (1.62 ± 0.27 x10<sup>-3</sup>) than normal tissues (3.06 ±0.51 x10<sup>-3</sup>, Wilcoxon Ranked Sum Test z= 0.003 and power=0.98). These results imply that the water in tumors behaves more like free water than the water in normal tissue.
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