Abstract
Hypertension and diabetes are the major risk factors for patients with Coronavirus disease 2019 (COVID-19). The physiological link between the diseases is still obscure. A growing body of evidence indicates that Angiotensin-converting enzyme 2 (ACE2) could be one of the critical agents linking diabetes with hypertension and COVID-19. Whether an up- or rather a down-regulation of ACE2 is responsible for the higher risk for COVID-19 is not clear. Experimental evidence and theoretical models exist for both. We show here that in addition to the overall up-/down-regulation of ACE2 at the whole-body level, we need to consider the tissue- and cell-specific dysregulations of ACE2, determining the risk of patients with diabetes for COVID-19.
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