Tissue adhesives in corneal lesions

Abstract

Abstract Purpose To evaluate the use of fibrin and cyanoacrylate glues in corneal wounds. Methods Eight albino rabbits were used (16 eyes) for the comparison of different types of adhesions. After the creation of corneal wounds, the fibrin glue (Beriplast) was used in the right eyes of the rabbits, while the cyanoacrylate glue (Gluebran) was applied in the left eyes. Follow up examinations, under the microscope, were performed in 1, 3 and 10 months, for the evaluation of the wound and the surrounding corneal tissue. Results The cyanocrylate glue was polymerized almost immediately after the application on the tissue, thus deteriorating the ability of the surgeon to reconstruct the wound appropriately. Neovascularization and clouding of the corneal tissue around the wound was present in all the follow up examinations. The fibrin glue was polymerized more gradually giving to the surgeon enough time for manipulations to reconstruct the wound properly. Less neovascularization and clouding were observed especially if the two components of the fibrin glue were mixed before the application on the wound. Both glues were easier to manipulate and apply in cases of corneal tunnels so as to seal the entrance of the tunnel with very satisfactory results. Conclusion The use of the fibrin glue for the reconstruction of corneal wounds is easier than the use of the cyanoacrylate glue, with less tissue reaction postoperatively.