Tirofiban hydrochloride sodium chloride injection combined with cardiovascular intervention in the treatment of Acute Myocardial Infarction.

Yongxuan Liu,Lingling Zhang,Yanyan Yang

doi:10.12669/pjms.36.2.1005

Abstract

Objective:To investigate the therapeutic effect of tirofiban hydrochloride sodium chloride injection combined with cardiovascular intervention on acute myocardial infarction.Methods:Eighty-four patients with acute myocardial infarction who were treated in our hospital from April 2017 to May 2018 were divided into a control group and a treatment group using random number table method; there were 42 patients in each group. Both groups were given conventional treatment and were treated with aspirin and clopidogrel before and after operation. Moreover, the control group was treated with cardiovascular interventional therapy, while the treatment group was treated with tirofiban hydrochloride on the basis of cardiovascular interventional therapy. The patients were followed up to observe and compare the treatment condition and adverse reactions of the two groups.Results:After percutaneous coronary intervention, the normal rate of myocardial perfusion in the treatment group was 92.86%, which was higher than 69.05% in the control group (P<0.05). After PCI, there were significant differences of thrombolysis in myocardial infarction (TIMI) flow Grade- 2 and 3 between the two groups (P<0.05). The improvement of platelet activation function in the treatment group was better than that in the control group (P<0.05). The incidence of adverse cardiac events in the treatment group was significantly lower than that in the control group (P<0.05).Conclusion:Tirofiban hydrochloride sodium chloride injection combined with cardiovascular intervention has a significant clinical effect in the treatment of acute myocardial infarction. It can effectively improve the blood perfusion and reduce the incidence of adverse cardiac events, suggesting a good effect on the prognosis of patients and high application value.

Highlights

Acute myocardial infarction is a disease which occurs and progresses rapidly and has high mortality rate.[1,2,3] With the development of social economy and the changes of living habits of people, acute myocardial infarction has been one of the diseases which can threaten public health
Distal embolism may occur in the course of cardiovascular interventional therapy, slowing down the speed of blood perfusion, and no-reflow phenomenon will occur in severe cases, which will lead to adverse cardiovascular events in the prognosis of patients
Observation indicators and evaluation criteria: (1) thrombolysis in myocardial infarction (TIMI) Myocardial Perfusion Grading (TMPG) was performed within 15 minutes after percutaneous coronary intervention (PCI): grade 0 indicates that myocardial perfusion is not obvious; grade I indicates that the perfusion of contrast medium is slow; grade II indicates that there is a delay in contrast medium into and out of micro vessels; grade III indicates that contrast medium can be perfused effectively

Summary

Introduction

Acute myocardial infarction is a disease which occurs and progresses rapidly and has high mortality rate.[1,2,3] With the development of social economy and the changes of living habits of people, acute myocardial infarction has been one of the diseases which can threaten public health. Aspirin and clopidogrel are commonly used anti-platelet drugs in clinic and can be used for treating acute coronary syndrome, which can inhibit platelet aggregation and improve the prognosis of patients.[9] aspirin and clopidogrel can only block one way of platelet activation, and platelets can be activated and aggregated by other ways, which limits their clinical efficacy. Studies have shown that tirofiban hydrochloride sodium chloride injection can effectively inhibit platelet aggregation and improve patients’ cardiac function index.[10] In this study, 84 patients with acute myocardial infarction were selected to evaluate the therapeutic effect of tirofiban hydrochloride sodium chloride injection combined with cardiovascular intervention, in order to provide effective reference for clinical rational drug use

Methods

Results

Conclusion