Tip 1 Diyabette Serum Vitamin D Bağlayan Protein Düzeylerinin Araştırılması: Glisemik Kontrol ve Hastalık Süresinin Etkisi

Abstract

Aim: Patients with type 1 diabetes mellitus (T1DM) are known to be more prone to vitamin D deficiency. Vitamin D studies in this
 patient population have traditionally been performed using serum 25OHD levels. However, vitamin D binding protein (VDBP) has
 been less studied. This study aims to compare serum VDBP levels in T1DM with healthy controls. It also aims to investigate the factors
 affecting VDBP levels such as disease duration, HbA1c, insulin dose, and age in diabetic subjects.
 Material and Methods: A research study was conducted at Çanakkale Onsekiz Mart University Health Practice and Research Hospital.
 The study included 11-17 years old children with T1DM and healthy controls. Serum VDBP and 25OHD concentrations were compared
 with appropriate statistical methods according to the normal distribution of relevant parameters. For the diabetic subjects, insulin doses
 and duration of diabetes were recorded. Spearman’s correlation test was utilized to assess associations between continuous variables, and
 regression analysis was employed to determine predictors of serum VDBP levels.
 Results: The study enrolled 89 subjects, including 40 with diabetes. Serum 25OHD levels were similar in the T1DM group and control
 group (17.03 IQR:12.89-22.08) and (17.62 IQR:11.68-24.48), respectively (p=0.701). However, VDBP levels were significantly lower in
 the T1DM group (335 μg/ml, IQR: 199.8-517.2 μg/ml) compared to the control group (471.2 μg/ml, IQR: 368.3-533.2 μg/ml) (p < 0.015).
 In the entire group, only the presence of diabetes affected VDBP levels (B=87.236, SE=34.802, p=0.014). On the other hand, HbA1c,
 duration of diabetes, and insulin dose had no influence on VDBP in the diabetes group.
 Conclusion: Serum VDBP levels were significantly lower in T1DM patients but in this group, disease duration, insulin dose, and
 metabolic control did not affect serum VDBP levels. Serum VDBP concentrations in T1DM may be affected by other parameters rather
 than metabolic parameters. Therefore, future studies should focus on addressing this knowledge gap.