Tip 1 Diabetes Mellituslu Çocuklarda Uyarılmış Potansiyellerin Eş Zamanlı Kan Şekeri, Serum ve Hücre İçi Magnezyum Düzeyleri ve Glikozillenmiş Hemoglobin İle İlişkisi

Abstract

Type I Diabete s Mellitus is a chronic disease associated with high morbidity and complications. The aim of this study was to evaluate central nervous system involvement by evoked potentials in diabetic children and identify the relation with metabolic disturbances. The st udy comprised of 31 Type I diabetic children with aged 5-14 years and 35 age and sex matched controls. Visual, brainstem auditory and somatosensory evoked potentials, otoacoustic emissions were recorded in all subjects. Metabolic control was evaluated in terms of glyceamia, glycosylated haemoglobin, serum and intracellular magnesium status. Groups were compared due to metabolic processes, disease duration and evoked potentials. In the diabetic group, serum glucose and HbA1c levels were higher and serum magnesium levels were lower (p 0.05). The significant difference of the evoked potentials in the diabetic groups was highly related with HbA1c and serum and intracellular magnesium levels as well as blood glucose levels and duration of diabetes (p<0.05). In conclusion, central nervous system involvement, highly related with synchronous blood glucose, glycosylated haemoglobin, duration of diabetes, serum and intracellular magnesium levels may be the earliest complication in diabetes mellitus that can be detected by evoked potentials. We consider that serum and intracelluler magnesium levels and evoked potentials will be useful in the routine follow up of diabetes mellitus.