TiO2‐SiO2 nanocomposite‐promoted efficient cyclocondensation reaction of arylmethylidenepyruvic acids with dimedone in aqueous media

Abstract

This work focuses on the successful synthesis of 4‐aryl‐7,7‐dimethyl‐5‐oxo‐1,4,5,6,7,8‐hexahydro‐2‐quinolinecarboxylic acids through a condensation reaction of arylmethylidenepyruvic acids with ammonium acetate and dimedone using a catalytic amount of TiO2–SiO2 nanocomposite (15 mol%) at room temperature in aqueous media. The principal advantage of this procedure is the relatively high yields (94–98%) with short reaction times (2 hr), under mild reaction conditions and with low environmental impact.