Abstract
Background TiO2 nanoparticles (TiO2 NPs) are extensively used metal oxide NPs in cosmetics, as an additive in pharmaceuticals, food colorant etc. Being widely used NPs, their toxicity assessment studies help in understanding the adverse effects to the humans. It is likely that NPs exposure to the humans can be through different routes but will finally reach the liver. Therefore, an attempt was made to explore the genotoxicity of TiO2 NPs on human liver cells (HepG2).
Highlights
TiO2 nanoparticles (TiO2 NPs) are extensively used metal oxide NPs in cosmetics, as an additive in pharmaceuticals, food colorant etc
Materials and methods TiO2 NPs were characterized by transmission electron microscopy (TEM) for their primary size, shape and dynamic light scattering for their size, size distribution and zeta potential in culture medium
A significant (p < 0.05) induction in micronucleus formation was observed at 20 μg/ml of TiO2 NPs exposure when compared to control cells
Summary
TiO2 nanoparticles (TiO2 NPs) are extensively used metal oxide NPs in cosmetics, as an additive in pharmaceuticals, food colorant etc. Being widely used NPs, their toxicity assessment studies help in understanding the adverse effects to the humans. It is likely that NPs exposure to the humans can be through different routes but will reach the liver. An attempt was made to explore the genotoxicity of TiO2 NPs on human liver cells (HepG2)
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