Tinospora cordifolia (Amruthballi): Medicinal plant with Anticancer activity

Abstract

This review paper highlights the therapeutic properties of Tinospora cordifolia (Amruthballi), Giloy’ or ‘Guduchi’ particularly anticancer activity. Nine species of Tinospora are naturalized in the different states of India. Tinospora cordifolia is one such plant and has shown to exhibit anti-carcinogenic properties. Tinospora cordifolia herbal supplements have recently gained prominence due to their promising immunomodulatory, and anticancer properties. Berberine (BBR) is a natural active principle with potential antitumor activity. Significant anti-carcinogenic properties were exhibited by Tinospora cordifolia-derived phytocompounds including palmative, berberine, new clerodane furanoditerene glycoside, arabinogalactan, phenolic compounds and epoxy cleodane diterpene. Cancer is an extreme metabolic disorder that has seen significant advancement in treatment plans and preventative remedies. It is also called neoplastic disease, characterized by the uncontrolled proliferation followed by the constant multiplication of human cells. This leads to the development of tumors of harmful malignant cells with the capacity to be metastatic. These plant derived natural resources have proved to be non-toxic and are potential modes of cancer management and therapy. Tinospora cordifolia extracts demonstrated the potent analogs possess multiple effects on numerous molecular targets of malignant cells. These analogs can be developed as non-toxic and therapeutically effective drug products to combat various malignancies.