Abstract
A series of five coordinated diorganotin(IV) unsymmetrical Schiff base complexes have been synthesized. The structure determination and characterization of these complexes were made on the basis of UV-Vis, IR, ( 1 H and 119 Sn) NMR spectroscopy as well as elemental analysis. The binding site of the ligand was identified by IR spectroscopic measurement. Computational analyses at the level of DFT were performed to study its electronic and molecular structures. The molecular geometry, infrared vibrational frequencies, HOMO-LUMO energy gap, dipole moment, Mulliken charges, HF energies were calculated. The theoretical results were consistent with the experimental data reported. The Schiff base ligands and synthesized tin(IV) complexes were screened for their in vitro growth inhibiting activity against different strains of bacteria. Results indicated that the complexes exhibited good antibacterial activities than the ligands. Also the thermodynamic formation constants of the Schiff bases as donors with Me 2 SnCl 2 as an acceptor were measured using UV-Vis spectrophotometric titration for 1:1 complex formation at constant ionic strength (I = 0.1 M NaClO 4 ) and at 25 oC. KEY WORDS : Tin(IV) complexes, Thermodynamic parameter, Biological activity, Computational analyses Bull. Chem. Soc. Ethiop. 2019 , 33(1), 77-90 DOI: https://dx.doi.org/10.4314/bcse.v33i1.8
Highlights
The discovery of several new organotin species and new applications has led to a renewed interest in organotin complexes
Schiff base ligands received instant and enduring popularity because they have played a seminal role in the development of modern coordination chemistry, as well as they can be found at key points in the development of inorganic chemistry, catalysis, pigment and dyes, medicinal imaging, optical materials and thin films [5,6,7,8]
Schiff base ligands containing hetero atoms such as N, O, and S show a broad biological activity and are of special interest because of their variety of ways in which they are interacted to metal ions
Summary
The discovery of several new organotin species and new applications has led to a renewed interest in organotin complexes. Schiff base in neutral and deprotonated forms react with organotin(IV) halides and the complexes extensively studied because they have some characteristics properties like manifestations of novel structures, thermal stability, high synthesis flexibility, medicinal utility, industrial applications and relevant biological properties [9,10,11,12]. In addition to their special antimicrobial activities, organotin(IV) compound with Schiff bases present an interesting variety of structural possibilities, so that a remarkable diversity in structure may be observed even when only a small change in the chemistry occurs [13]
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