Abstract
Book’s topic Liquid chromatography is one of the most important methods of chemical analysis used in analytical laboratories. Various theories and models of chromatography have been developed and have long been widely applied in analytical chromatography. All of those theories assume that a minute amount of sample is being analyzed, as this assumption results in relatively simple models. Although chromatography was born as a preparative rather than analytical tool, the theory of chromatography with finite sample sizes is less understood, even though it has been studied continuously for many years. This is due to the complexity of the separation process when the column is overloaded. This book covers the mathematical modeling of nonlinear chromatography, which is inevitable when planning and optimizing purification with preparative chromatography. Nevertheless, once one understands the modeling of nonlinear chromatography, those theories can be usefully employed to gain a better understanding of analytical liquid chromatography, which can be considered the limit of nonlinear chromatography for dilute samples. This book is the second edition, which is enlarged compared to the first edition (published in 1995).
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