Abstract
Background: Cleft lip and palate (CLP) can affect the development of the maxilla; which may create a midfacial deficiency as well as an interference of the facial growth pattern and dentofacial esthetics. Objective: This study aimed to estimate the chronological age of complete fusion of the spheno-occipital synchondrosis (SOS) in cleft lip and palate patients and a control group; using cone beam computed tomography (CBCT) images. Methods: In this retrospective study; 125 patients were enrolled (cleft lip and palate group (n = 91); control group (n = 34)). Age comparison was made with a chi-square test; and a Kaplan–Meier analysis determined the median time to reach complete fusion of the spheno-occipital synchondrosis (p < 0.05). Results: The experimental group showed statistically significant differences in the median time for complete ossification between males and females (p = 0.019). The median time for complete ossification of the spheno-occipital synchondrosis was; for males; 15.0 years in both groups; for females; it was 14.0 years and 13.0 years in the experimental group and in the control group; respectively. Both for males and females; there were no statistically significant differences between experimental and control groups (p = 0.104). Conclusions: The present study showed no differences in the ossification of the spheno-occipital synchondrosis between individuals with and without cleft lip and/or palate.
Highlights
Patients with isolated cleft lip and palate (CLP) have an anatomical defect that may occur during the 4th and 12th weeks of pregnancy [1,2]
Cleft lip and palate (CLP) is known to affect the development of the maxilla by a combination of functional, intrinsic and iatrogenic factors, which may lead to a retruded position of the maxilla and create a midfacial deficiency, negatively influencing the facial growth pattern and dentofacial esthetics [4,5,6,7]
The purpose of this study was to estimate the chronological age of complete ossification of the spheno-occipital synchondrosis in cleft lip and/or palate patients and a control group, using cone beam computed tomography (CBCT) images
Summary
Patients with isolated cleft lip and palate (CLP) have an anatomical defect that may occur during the 4th and 12th weeks of pregnancy [1,2]. Cleft lip and palate (CLP) can affect the development of the maxilla; which may create a midfacial deficiency as well as an interference of the facial growth pattern and dentofacial esthetics. Objective: This study aimed to estimate the chronological age of complete fusion of the spheno-occipital synchondrosis (SOS) in cleft lip and palate patients and a control group; using cone beam computed tomography (CBCT) images. The median time for complete ossification of the spheno-occipital synchondrosis was; for males; 15.0 years in both groups; for females; it was 14.0 years and 13.0 years in the experimental group and in the control group; respectively. Both for males and females; there were no statistically significant differences between experimental and control groups (p = 0.104)
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