Timing of elective termination of Pregnancy in Preterm Premature Rupture of membranes, prospective randomized controlled trial.

Abstract

Background: Rupture of membranes is associated with high incidence of maternal and fetal morbidities as well as the neonatal morbidity and mortality resulting from prematurity if preterm birth ensues.Aim: This study aimed to evaluate maternal and neonatal outcomes of elective delivery at 34 versus 36 weeks of gestations in pregnancies complicated by preterm premature rupture of membranes and had been managed expectantly.Materials and Methods: This is a prospective randomized controlled trial which was conducted at Ain Shams University Maternity hospital between March and August 2019. 140 women pregnant between 30 and 32 weeks and diagnosed with preterm premature rupture of membranes were admitted to receive conservative management and then they were randomly divided into 2 equal groups regarding time of elective delivery either late delivery at 36 weeks or early delivery at 34 weeks.Results: The incidence of intrauterine infections was comparable between both groups. The rate of chorioamnionits was 8.6% in the late delivery group versus 4.3% in the early delivery group while endometritis was diagnosed in 2.9% in the late delivery group and 1.4% in the early delivery group. The incidence of spontaneous onset of preterm labor, cord prolapse and placental abruption was similar in both groups. Neonates of the late delivery group had significantly more Apgar score at 5 minutes (6.4±1.0 versus 5.0±0.9, p 0.05).Conclusion: Early delivery at 34 weeks does not reduce the rate of chorioamnionitis, but does increase the likelihood of respiratory distress syndrome and the rate of neonatal intensive care unit admissions. Our findings support the practice of conservative management in pregnant women with ruptured membranes if there is no contraindication to extending the pregnancy.