Timing of Dose-Finding Studies: Before or After Completion of a Randomized Clinical Trial?

Abstract

To the Editor .— Ghanta et al1 reported that in preterm infants (median gestational age: 27–28 weeks; median postnatal age: 3–4 days), the use of propofol is more effective than a morphine, atropine, and suxamethonium regimen as an induction agent to facilitate neonatal nasal endotracheal intubation. In their well-designed randomized, controlled clinical trial, they used a single 2.5 mg/kg intravenous dose and based their selection of this …