Abstract
Investigators from the Pediatric Status Epilepticus Research Group studied the time elapsed from onset of pediatric convulsive status epilepticus (SE) to administration of antiepileptic drugs (AED).
Highlights
Current status epilepticus (SE) treatment protocols recommend a timely administration of AED doses and a rapid escalation between different classes of AED’s [2]
Results from animal models showed that prolonged SE causes brain damage [4], and the response to benzodiazepines decreases with seizure duration [5, 6]
While these data suggest the importance of rapid AED administration in SE, there is limited literature on the timeliness of AED administration in clinical practice
Summary
Current status epilepticus (SE) treatment protocols recommend a timely administration of AED doses and a rapid escalation between different classes of AED’s [2]. The rationale for this recommendation includes results from clinical studies suggesting better seizure control and reduction of brain injury with earlier AED administration [3].
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