Timing and amplitude of gamma-band deactivation in default-mode network is correlated with behavior

Abstract

Event Abstract Back to Event Timing and amplitude of gamma-band deactivation in default-mode network is correlated with behavior Tomas Ossandon1*, Karim Jerbi1, Juan R. Vidal1, Dimitri Bayle1, Olivier Bertrand11, Philippe Kahane2 and Jean-Philippe Lachaux1 1 Lyon Neuroscience Research Center, France 2 Neurology Department, Grenoble University Hospital, France Task-related deactivations, described in the default mode network (DMN) literature, have been predominantly reported with functional imaging studies (Raichle et al., 2001). Therefore, the electrophysiological correlates and the fine-scale temporal dynamics of this phenomenon are still poorly understood. Given that recent animal studies as well as recent findings in humans (Niessing et al., 2005) suggest correlations between the BOLD signal and gamma-band activity, we posit that gamma deactivation may provide an electrophysiological correlate of the DMN. To test this hypothesis we examine the spatial and temporal pattern of high gamma (60-140 Hz) power suppression using intracranial EEG recordings simultaneously from widespread cortical structures in subjects performing a visual search task. We used direct recordings of neural activity in 15 epileptic patients implanted with depth electrodes for therapeutic purposes. The subjects performed a visual search paradigm with variable levels of task difficulty. We use time-frequency analysis to assess the presence, duration and intensity of gamma band power induced by the display of the search array. We found that all DMN areas displayed transient suppressions of gamma (60-140 Hz) power during task performance and, critically, the duration and extent of this broadband suppression were correlated with task complexity and subject performance. Furthermore, trial-by-trial correlations revealed that spatially distributed gamma activations and deactivations formed distinct anticorrelated networks. These findings facilitate our understanding of the relationship between electrophysiology and neuroimaging studies in humans and indicate that neural deactivations encode the duration and efficiency of our engagement with the external world. Funding: Fondation pour la Recherche Medicale (FRM) and BrainSync FP7 European Project (Grant HEALTH-F2-2008-200728). Keywords: gamma band, Intra-cranial Electrophysiology Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Abstracts Citation: Ossandon T, Jerbi K, Vidal JR, Bayle D, Bertrand1 O, Kahane P and Lachaux J (2011). Timing and amplitude of gamma-band deactivation in default-mode network is correlated with behavior. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00065 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Nov 2011; Published Online: 25 Nov 2011. * Correspondence: Dr. Tomas Ossandon, Lyon Neuroscience Research Center, Lyon, France, tossandon@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Tomas Ossandon Karim Jerbi Juan R Vidal Dimitri Bayle Olivier Bertrand1 Philippe Kahane Jean-Philippe Lachaux Google Tomas Ossandon Karim Jerbi Juan R Vidal Dimitri Bayle Olivier Bertrand1 Philippe Kahane Jean-Philippe Lachaux Google Scholar Tomas Ossandon Karim Jerbi Juan R Vidal Dimitri Bayle Olivier Bertrand1 Philippe Kahane Jean-Philippe Lachaux PubMed Tomas Ossandon Karim Jerbi Juan R Vidal Dimitri Bayle Olivier Bertrand1 Philippe Kahane Jean-Philippe Lachaux Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.