Abstract
Timescales of learning in the basal ganglia and the hippocampus
Highlights
Recent theoretical and experimental considerations have, led to the hypothesis that hippocampal function is, to the striatum, dependent on signals from subcortical nuclei that are sensitive to environmental forms of feedback such as reinforcing stimulation (e.g., Gaffan, 2002; Martig and Mizumori, 2011)
There has been a distinction between basal ganglia dependent and hippocampus dependent memory systems (e.g., Squire, 1992)
The failure to learn from delayed feedback in patients with hippocampal lesions could be related to the loss of function of area CA1, since CA1 receives afferents from areas known to respond phasically to reinforcing stimulation (Gasbarri et al, 1994; Martig and Mizumori, 2011) and appears to be critically involved in temporal analysis when there are long delays among relevant stimuli (e.g., Hunsaker and Kesner, 2008; Farovik et al, 2010)
Summary
Recent theoretical and experimental considerations have, led to the hypothesis that hippocampal function is, to the striatum, dependent on signals from subcortical nuclei that are sensitive to environmental forms of feedback such as reinforcing stimulation (e.g., Gaffan, 2002; Martig and Mizumori, 2011). Compelling evidence of the role of reinforcing stimulation on hippocampal mediated learning comes from experiments analyzing the theta rhythm (5–12 Hz) in the hippocampus of the behaving rat (for a review see Vertes, 2005).
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