Abstract
BackgroundExperiencing a lower limb amputation (LLA) or spinal cord injury (SCI) is a life-changing event, affecting physical and systemic function as well as having psychological and social impacts. However, the severity of the physical impairment and/or motor disability demonstrates a poor relationship with patient-reported quality of life, suggesting that other factors determine such outcomes. As such, holistic health-related quality of life (QoL) assessment is an important tool to monitor long-term outcomes. While there are some studies that have assessed the influence of variables such as age at time of injury occurrence and time since injury on changes in QoL, there are no systematic reviews which synthesise this evidence.Methods/designAll follow-up study designs will be included, where data from multiple time points are presented. Searches will target both SCI and LLA populations where a validated measure of QoL has been used: Medical Outcome Study Short-Form 36/12 or the World Health Organization Quality of Life instruments 100 and BREF. Studies must include adult participants (≥ 18 years at time of injury) and detail time since injury event and patient age.The primary objective is to establish the effects of participant age and time since injury on QoL scores. Secondary objectives include determining between-group effects (i.e. LLA vs. SCI).We will search PubMed, Embase and Web of Science databases, supplemented by hand-searching references within existing review articles and experimental studies. Reviewer pairs will conduct screening and quality assessment of included papers.Results will be stratified by impairment, QoL tool, age/time since injury and additional variables such as sex, race, comorbidity or disease aetiology, as appropriate. If sufficient high-quality data exist, a meta-analysis will be conducted.DiscussionThe results of this systematic review will summarise evidence of how QoL changes across the life course, relative to both patient age and time since injury, for both LLA and SCI populations. By enabling a direct comparison of different chronic conditions, disability-specific differences in QoL changes over the life course can be identified.Systematic review registrationPROSPERO CRD42018096633.
Highlights
Experiencing a lower limb amputation (LLA) or spinal cord injury (SCI) is a life-changing event, affecting physical and systemic function as well as having psychological and social impacts
The results of this systematic review will summarise evidence of how quality of life (QoL) changes across the life course, relative to both patient age and time since injury, for both LLA and SCI populations
Methods/design This protocol follows the principles of The Cochrane Handbook for Systematic Reviews, and the final report will conform to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses [52, 53]
Summary
Experiencing a lower limb amputation (LLA) or spinal cord injury (SCI) is a life-changing event, affecting physical and systemic function as well as having psychological and social impacts. Sustaining a lower limb amputation (LLA) or spinal cord injury (SCI) is a significant event, with permanent implications for the individual’s future life. The outcomes of both LLA and SCI are highly individualised and heterogeneous, in part due to variability in the level of injury/ amputation and, at least for SCI, the degree of injury completeness. The reasons for injury occurrence can be important, with many LLA cases being related to significant existing chronic disease and related comorbidities Both conditions present a series of shared outcomes that have a significant impact on aspects of quality of life (QoL) [1]. A general loss of skeletal muscle mass and restriction of physical activity contribute to longterm health consequences associated with early ageing [12, 13] such as increased risk of cardiovascular and metabolic diseases [14,15,16]
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