Abstract
In many jurisdictions large data sets on malformations are now collected routinely in order to define prevalence rates of malformations in infants and children, to detect long-term secular trends, and to ascertain cases for ad hoc case-control studies. With slight modifications, these data sets may be used for prompt surveillance of changes in the birth prevalence of malformations, changes that conceivably could be possibly due to the introduction of a teratogen into the environment. A specific logistic approach is suggested, modeled on the New York State Malformation Registry, for prompt detection of changes in rates.
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