Abstract
Time-tuning cancer therapy
Highlights
Personalized medicine in cancer is based on targeted therapy, often defined as the right drug to the right patient
We have evaluated the signaling pathways preponderantly activated by wound fluids (WF), using a large panel of breast cancer (BC) cell lines
Constitutive activity of STAT3 has been observed in 35% to 60% of human breast tumors and in many BC cell lines
Summary
Personalized medicine in cancer is based on targeted therapy, often defined as the right drug to the right patient. We have evaluated the signaling pathways preponderantly activated by WF, using a large panel of BC cell lines. Strong and specific activation of the STAT3 pathway was consistently observed [7].
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