Time to surgery increases pre-operative il-6 and fibrinogen levels in elderly patient with proximal femoral fracture

Abstract

Introduction: Proximal femoral fractures are often found in elderly patients who often suffer from other diseases too. Therefore, comprehensive perioperative management is needed. Preparation for pre-operation will result in a longer waiting time than the time recommended in general. Time to surgery is associated with an increased risk of inflammation and thromboembolism, but many studies show contradictory results. Methods: to find out the correlation between time to surgery and interleukin-6 and fibrinogen levels pre-operatively in elderly patients with proximal femoral fractures. This study was an analytic cross-sectional study in 31 elderly patients with proximal femoral fractures. Interleukin-6 and fibrinogen levels were measured one hour before surgery. Results : Of the 31 patients aged ≥ 60 years with a proximal femoral fracture, the average age was 74 years old and the incidence of fracture was most common in women compared to men. The time to surgery is determined from the time the trauma occurred until surgery. There is a significant correlation between time to surgery and IL-6 levels (r 0.673; p <0.05). A significant correlation also found between time to surgery and fibrinogen levels (r 0.747; p <0.05). Conclusion: From the results of statistical analysis, it was concluded that the time to surgery was significantly associated with an increase in Interleukin-6 as an inflammatory marker and also with fibrinogen as a possible marker of venous thromboembolism.