Time to Give It Arrest? Preclinical Evidence of Epinephrine-associated Worsening of Outcomes in a Novel Mouse Model of Cardiac Arrest

Abstract

Epinephrine (EPI) use in the resuscitation of cardiac arrest (CA) patients improves short-term recovery of spontaneous circulation (ROSC) with paradoxically equal or worse long-term outcomes. Due to nuanced cofounding variables in the clinical setting (e.g., early spontaneous recovery precluding use of epinephrine) there is critical need for preclinical models to interrogate the impact of epinephrine in CA.