Abstract
Intermittent fasting (IF) is a non-pharmacological dietary approach for intervening into aging in different organisms. We evaluated the efficacy of time restricted dietary regimen and alternate-day fasting in rats by measuring redox parameters which are frequently used as signature biomarkers of aging. Wistar rats (8 months) were divided into three groups of six rats each. Group I: Control; Group II: Time-restricted feeding (TRF) (fed and fasted at a ratio of 16:8 h respectively) and Group III. Alternate day feeding (ADF) (fed and fasted on alternate days), for a period of 1 month. The biomarkers of antioxidant defense and oxidative stress: FRAP, GSH, PMRS, ROS, AGE, MDA, PCO, AOPP, TNF-α and IL-6, were determined. Our results suggest that, based on predominant aging biomarkers, TRF has a similar effect on rats compared with ADF evaluated in terms of redox homeostasis. Observed results defend our purpose that the ADF and TRF methods are reliable dietary restriction regimens and subsequently improve the metabolic profile and redox homeostasis in rats.
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