Abstract
Ruthenium(II) polypyridine complexes of imidazophenanthrolines are widely studied as photosensitizers for photodynamic therapy. The effectiveness of a therapeutic drug is manifested in its high cytotoxicity. Nowadays, the main methods for evaluating the drug effectiveness are still expensive and time-consuming photobiological studies on cell lines. It would be convenient to have access to simpler but no less reliable methods for evaluating the therapeutic efficacy. This review highlights recent investigations on the correlations between the photophysical behavior of ruthenium(II) complexes and their photobiological efficacy, as well as the possibilities of femto- and nanosecond time-resolved photophysical studies to establish the therapeutic efficacy.
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