Abstract
The time of development and the duration of the effect of a guinea pig antihomograft transfer factor has been studied. The factor is demonstrable in the lymph nodes by the seventh or eighth day after grafting. The capacity for causing a cutaneous inflammatory reaction in the donor and inducing the accelerated rejection of donor skin grafts arises and declines at the same rate. By injecting the factor prior to grafting it is shown that it has a short-lived effect. The data are consistent with the characteristics of the development, duration, and passive transfer of antibodies.
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