Time-limited access to palatable food reveals differential effects of psychological stress on homeostatic vs. hedonic feeding behavior in male rats

Abstract

Psychological stress has complex effects on eating behavior, appearing to reduce homeostatically regulated feeding, while increasing hedonically motivated feeding. The present work tests this idea using two feeding paradigms that offer a highly palatable food on a time-limited basis, together with continual access to a low palatability food. This approach provides a natural separation between periods of eating that are primarily homeostatic vs. hedonically regulated. First, the impact of acute stress exposure on feeding behavior was tested using an acute “meal-dessert” paradigm. When fasted adult male rats were given a recent stressor of moderate intensity (restraint), refeeding with a chow-meal was reduced, without affecting chocolate-dessert intake, thereby increasing the proportion of calories derived from chocolate. Next, the effect of chronic moderate stress was tested using a “binge” eating paradigm. Chow-fed rats were given unexpected (3d per week) vs. expected (7d per week) brief access to a highly palatable high-fat diet (HFD), and feeding behavior was compared to control groups that were maintained with continuous access to only chow or only HFD. Chronic stress reduced total caloric intake in all groups, including binge-like HFD intake. Binge-like HFD intake caused metabolic dysfunction (increased adiposity and impaired glucose homeostasis) to an extent beyond that predicted by total caloric intake or body weight gain. Finally, binge-like HFD intake shifted stress coping behavior from an active to a passive phenotype, particularly in rats receiving concurrent chronic stress, suggesting the possibility of increased risk for stress-related disorders, like depression, in individuals who binge eat during stress.